What exogenous conditions are responsible for increased cortisol secretion?
Cushing disease is caused by a tumor or excess growth (hyperplasia) of the pituitary gland. The pituitary gland is located just below the base of the brain. A type of pituitary tumor called an adenoma is the most common cause. An adenoma is a benign tumor (not a cancer). Show With Cushing disease, the pituitary gland releases too much ACTH. ACTH stimulates production and release of cortisol, a stress hormone. Too much ACTH causes the adrenal glands to make too much cortisol. Cortisol is normally released during stressful situations. It also has many other functions, including:
Symptoms of Cushing disease include:
Skin changes that are often seen include:
Muscle and bone changes include:
Women may have:
Men may have:
Other symptoms or problems may include:
The health care provider will perform a physical examination and ask about your symptoms. Tests are done first to confirm there is too much cortisol in the body, and then to determine the cause. These tests confirm too much cortisol:
These tests determine the cause of the high cortisol once it is confirmed:
Other tests that may be done include any of the following:
More than one screening test may be needed to diagnose Cushing disease. Your provider may ask you to see a doctor who specializes in pituitary diseases. Treatment involves surgery to remove the pituitary tumor, if possible. After surgery, the pituitary gland may slowly start to work again and return to normal. During the recovery process from surgery, you may need cortisol replacement treatments because the pituitary needs time to start making ACTH again. Radiation treatment of the pituitary gland may also be used if the tumor is not completely removed. If the tumor does not respond to surgery or radiation, you may need medicines to stop your body from making cortisol. If these treatments are not successful, the adrenal glands may need to be removed to stop the high levels of cortisol from being produced. Removal of the adrenal glands can cause the pituitary tumor to get much bigger (Nelson syndrome). Untreated, Cushing disease can cause severe illness, even death. Removal of the tumor may lead to full recovery, but the tumor can grow back. Health problems that may result from Cushing disease include:
Call your provider if you develop symptoms of Cushing disease. If you have had a pituitary tumor removed, call your provider if you have signs of complications, including signs that the tumor has returned. Pituitary Cushing disease; ACTH-secreting adenoma Juszczak A, Morris DG, Grossman AB, Nieman LK. Cushing's syndrome. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 13. Newell-Price JDC, Auchus RJ. The adrenal cortex. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 15. Weiss RE. Anterior pituitary. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 211. Updated by: Brent Wisse, MD, Board Certified in Metabolism/Endocrinology, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. What causes increased secretion of cortisol?Regulating your body's stress response: During times of stress, your body can release cortisol after releasing its “fight or flight” hormones, such as adrenaline, so you continue to stay on high alert. In addition, cortisol triggers the release of glucose (sugar) from your liver for fast energy during times of stress.
Which condition is caused by prolonged exposure to high levels of cortisol?Cushing's syndrome, also called hypercortisolism, is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland.
What controls the production of cortisol?The hypothalamus-pituitary-adrenal axis regulates both production and secretion of cortisol.
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