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Risk: High
Types of Agents: Those that may cause serious or lethal disease via inhalation. Effective treatment available.
Examples of Agents: Bacillus anthraces, Fancisella, Brucella, Mycobacterium tuberculosis, Rickettsia rickettsia, Coxiella burnetii, mold stages of systemic fungi
Precautions: Same as above plus negative air flow, sealed windows.
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Dangerous/exotic agents, high individual risk of aerosol-transmitted laboratory infection, frequently fatal, no vaccines or treatment.
Unknown risk of transmission
Agent similar to another used in a BSL-4 lab
sealed, negative pressure; All work must be performed within an appropriate Class III BSC [A gas-tight sealed container that is designed to allow for the manipulation of objects], hazardous substances, or infectious disease agents. Class III BSCs have a HEPA filtered air supply and double HEPA filtered exhaust. They provide the ultimate protection for personnel, product, and the environment.
-seperate building or isolated zone with dedicated supply of air
Shower on exit, clothing change before entry, decontaminate before exiting
Full body, air supplied positive pressure suit
Ex: Ebola