Which class of Antidysrhythmic drug delays repolarization and prolongs the effective refractory period?
Last updated: March 18, 2022 Show SummaryAntiarrhythmic drugs are used to prevent recurrent arrhythmias and restore sinus rhythm in patients with cardiac arrhythmias. These drugs are classified based on their electrophysiological effect on the myocardium. Antiarrhythmic drugs do not improve the survival of patients with non-life-threatening arrhythmias and may increase mortality, particularly in patients with structural heart disease. They are associated with severe adverse effects, primarily due to their proarrhythmic effects on the myocardium. Patients who have received an intravenous antiarrhythmic should be monitored closely with serial ECGs. Several classes of antiarrhythmics, including beta blockers, calcium channel blockers, amiodarone, cardiac glycosides, and lidocaine, also have other medical uses, which are discussed in their respective articles. Overview
All antiarrhythmic drugs are also potentially proarrhythmic! Intravenous administration should only be performed with continuous cardiac monitoring! “I am Ambivalent about the QUEEn PROofreading my DISsertation”: Class IA antiarrhythmic
drugs are QUEEnidine, PROcainamide, DISopyramide. Diltiazem and Verapamil Diminish conduction Velocity. Class IB antiarrhythmic drugs work Best after myocardial infarction; class IC antiarrhythmic drugs are Contraindicated. References:[6][7][8] Other antiarrhythmic drugsAdenosine (drug) [1]
Avoid adenosine in patients with suspected pre-excitation tachycardia (e.g., WPW), because it may exacerbate the tachycardia via accessory pathway routes. Digoxin
Magnesium sulfate [1][13]
Ivabradine [14]
IVabradine slows depolarization in phase IV. References
What is a Class 3 Antidysrhythmic?Class 3 antiarrhythmics are drugs that block cardiac tissue K channels Channels The Cell: Cell Membrane . The medications in this class include amiodarone. It increases the duration of ventricular and atrial muscle action by inhibiting potassium channels and voltage-gated sodium channels.
Which antiarrhythmic drug prolongs repolarization?Intravenous amiodarone homogeneously prolongs ventricular repolarization in patients with life-threatening ventricular tachyarrhythmia.
Is a Class III antiarrhythmic drug which prolongs repolarization?Antiarrhythmic Drugs
Ibutilide is classified as a class III drug because it delays repolarization.
What are Class 4 antiarrhythmics used for?Class IV antidysrhythmic drugs are used to treat: Atrial fibrillation and flutter (rapid and irregular heartbeats in the upper chamber of the heart) Paroxysmal supraventricular tachycardia (abnormal fast beating of the heart above the lower chambers) Hypertension (high blood pressure)
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